Project CuraBone – Biofunktionalisierung der Trägermatrizen mit Osteogenese-fördernden Peptiden und VEGF Nanosphären

Basic data

Acronym:
CuraBone
Title:
Biofunktionalisierung der Trägermatrizen mit Osteogenese-fördernden Peptiden und VEGF Nanosphären
Duration:
15/12/2014 to 30/06/2018
Abstract / short description:
In the framework of the cooperation project between the Department of Oral and Maxillofacial Surgery and the company Curasan AG, resorbable ceramics for critical bone defects will be developed. The use of autologous bone material leads to considerable morbidity of the patient donor site. The immobilization of the ceramics with resorbable organic materials should improve the mechanical stability of the constructs.
Therefore, ceramic materials will be stabilized by the addition of organic components such as collagen, polylactic acid or gelatin. The immobilization method should not influence the ceramic properties e.g. porosity. After improvement of the mechanical stability, biofunctionalization strategies with RGD-peptides and VEGF-containing particles for an enhanced neoangiogenesis will be established. The biocompatibility and hemocompatibility of developed ceramic constructs will be tested in vitro and in vivo.
Keywords:
Tissue Engineering
ß-Trikalziumphosphat
mechanische Stabilität
Biofunktionalisierung
Osteogenese
Angiogenese

Involved staff

Managers

Faculty of Medicine
University of Tübingen

Local organizational units

University Centre of Dentistry, Oral Medicine and Maxillofacial Surgery
Center of Dentistry, Oral Medicine and Maxillofacial Surgery
Hospitals and clinical institutes, Faculty of Medicine

Funders

Berlin, Germany
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