Project MorphGrad – Morphogen-like properties of small RNA gradients: A new paradigm for the role of small RNAs in…

Basic data

Acronym:
MorphGrad
Title:
Morphogen-like properties of small RNA gradients: A new paradigm for the role of small RNAs in developmental biology
Duration:
01/03/2017 to 28/02/2019
Abstract / short description:
This fellowship will investigate the mechanisms by which small RNAs function as novel intercellular messengers that provide important developmental signals. By manipulating various small RNA gradient and target parameters, the proposed research seeks to understand how small RNA gradients are interpreted into sharp gene expression domains. The findings from the proposed experiments will provide important insight into the patterning properties of small RNA gradients, and their role in conferring robustness to developmental programs in both plants and animals. The approach taken is a multidisciplinary one that integrates mathematical modelling with qualitative experimental data, generated from a novel reporter system and state-of-the-art confocal imaging and image analysis. The outcome will be a new paradigm for how miRNAs function in development, which will provide important insight into the patterning properties of small RNA gradients.
Keywords:
Small RNA gradients
Mathematical modelling
Leaf development
Adaxial-Abaxial polarity
miRNA

Involved staff

Managers

Department of Biology
Faculty of Science
Faculty of Science
University of Tübingen
Department of Biology
Faculty of Science

Local organizational units

Center for Plant Molecular Biology (ZMBP)
Department of Biology
Faculty of Science

Funders

Brüssel, Belgium
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