Project MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis

Basic data

Title:
MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis
Duration:
01/01/2017 to 31/12/2019
Abstract / short description:
Mutations in genes encoding mitochondrial proteins underlie many human diseases with more
constantly being discovered. In addition gradual decline in mitochondrial function plays a role
in aging and complex disease phenotypes such as neurodegeneration and cancer. Our group
brings together scientist with complementary expertise that share a passion for understanding
the cross talk of mitochondria and the cellular environment. We propose to use this unifying
opportunity to shine a new light on an unexplored aspect of mitochondrial biology – how the
cross talk of mitochondria and the cell promotes homeostasis of the mitochondrial proteome
(proteostasis) in health and disease.
Keywords:
mitochondria
Mitochondrien
proteome
Proteom
Quality control

Involved staff

Managers

Faculty of Science
University of Tübingen
Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes

Local organizational units

Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes
University of Tübingen

Funders

Bonn, Nordrhein-Westfalen, Germany
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