Project PROOF – Penumbral Rescue by Normobaric O=O Administration in Patients With Ischaemic Stroke and Target Mismatch…

Basic data

Acronym:
PROOF
Title:
Penumbral Rescue by Normobaric O=O Administration in Patients With Ischaemic Stroke and Target Mismatch ProFile: A Phase II Proof-of-Concept Trial
Duration:
01/01/2017 to 31/12/2021
Abstract / short description:
Ischaemic stroke (IS) is one of the most common causes of death and the most common cause of chronic disability in the western world, most significantly affecting the ageing populations of high-income countries. It is caused by an occlusion of arteries that supply blood to the brain. Disruption of blood and oxygen supply to the brain leads to neuronal death in the ischaemic core within minutes. The hypoperfused-hypooxygenated tissue surrounding the ischaemic core, the penumbra, is at high risk for infarction over time but still salvageable. Intravenous thrombolysis (IVT) and mechanical thrombectomy (TBY) facilitate early vessel recanalization and thus survival of penumbral tissue. However, as viable penumbra fades rapidly, the therapeutic time window is narrow and many eligible patients do not reach specialized stroke centres early enough. Neuroprotective “bridging” strategies, sustaining the penumbra until reperfusion, may widen the therapeutic window, making recanalization treatments accessible to more patients and improve overall IS outcomes.
As ischaemic cell death is primarily mediated by hypoxia, increasing oxygen supply to the penumbra seems THE logical approach for neuroprotection in stroke. In human beings normobaric hyperoxygenation (NBHO) is easily achieved through inhalation humidified oxygen at high flow rates (i.e. ≥40L/min) leading to an inspiratory oxygen fraction (FiO2) of near 100%.
Keywords:
stroke
Schlaganfall
stroke
Schlaganfall
O2
Ischaemischer Schlaganfall
Europäische Förderung
NBHO

Staff

Managers

Faculty of Medicine
University of Tübingen

Contact persons

University Department of Neurology
Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Institute of Medical Genetics and Applied Genomics
Department of Diagnostic Laboratory Medicine
Hospitals and clinical institutes, Faculty of Medicine

Funders

Brüssel, Belgium
Help

will be deleted permanently. This cannot be undone.