Project Aktivierung der Neutrophilen Granulozyten bei Patienten mit Extracorporaler Kreislaufunterstützung

Basic data

Title:
Aktivierung der Neutrophilen Granulozyten bei Patienten mit Extracorporaler Kreislaufunterstützung
Duration:
01/06/2016 to 31/05/2018
Abstract / short description:
In patients with extracorporeal circulation (ECMO) pronounced Inflammations- and thrombosis processes run in parallel. Through the blood contact with foreign surfaces an extreme activation of coagulation with the full clinical picture of DIC, thrombus formation and a massive SIRS occurs. The anticoagulation in these patients is a challenge, as they on the one hand require a heparinisation due to the foreign material and, on the other hand, they have a bleeding diatheses due to coagulation factors consumption and hyperfibrinolysis. As part of thrombotic material are NETs (Neutrophil Extracellular Traps) a potential target for anti-thrombotic and anti-inflammatory therapy simultaneously, but without increasing the risk of bleeding.
The aim of the project is to investigate the role of neutrophils and their NETs in above-mentioned processes in ECMO patients. Healthy controls and intensive care patients will serve with SIRS as a comparison collective.
There are so far no studies on neutrophils behaviour under ECMO therapy, e.g. how strong they are activated and how much NET-material is being released.
The aim of the current project is to study granulocyte activation and NETosis markers in ECMO patients and to compare those to matched controls.
Keywords:
ECMO
NETose

Involved staff

Managers

Faculty of Medicine
University of Tübingen

Contact persons

Faculty of Medicine
University of Tübingen
Faculty of Medicine
University of Tübingen

Local organizational units

Paediatrics Department II and Polyclinic
University Children’s Hospital - Department of Paediatrics
Hospitals and clinical institutes, Faculty of Medicine

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