Project Using high throughput screens in yeast to investigate the pathomechanism of Barth syndrome

Basic data

Title:
Using high throughput screens in yeast to investigate the pathomechanism of Barth syndrome
Duration:
01/05/2016 to 30/04/2017
Abstract / short description:
Barth syndrome occurs due to mutations in the mitochondrial protein, Tafazzin – a key enzyme in remodeling of the specific mitochondrial phospholipid, cardiolipin (CL). Our general aim is to understand in depth the biology underlying the pathophysiology of Barth syndrome. To do this we will follow three major aims: (i) Uncover the human Cardiolipin Phospholipase A, (ii) Map the cellular effects of losing Taffazin function and re-modeled cardiolipin, and (iii) Decipher the pathways enabling correct localization of yeast Taffazin.
Keywords:
mitochondria
Mitochondrien
Barth syndrome
Cradiolipin
TAZ1

Involved staff

Managers

Faculty of Science
University of Tübingen
Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes

Local organizational units

Interfaculty Institute of Biochemistry (IFIB)
Interfaculty Institutes
University of Tübingen

Funders

Larchmont, New York, United States of America
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