Project VolkswagenStiftung – Cellular mechanisms of healthy brain ageing under caloric restriction

Basic data

Acronym:
VolkswagenStiftung
Title:
Cellular mechanisms of healthy brain ageing under caloric restriction
Duration:
01/04/2016 to 31/03/2019
Abstract / short description:
Using biochemical, electrophysiological and in vivo/in situ imaging approaches the following specific aims will be addressed: 1) Characterization of the biochemical (energetic balance, efficiency of glycolysis and mitochondrial function, oxidative stress intensity) and physiological (at the single cell and network level) status of the ageing brain. 2) Comparison of the extent of ageing-induced deregulation of brain function in control and CR animals. 3) Deciphering cellular/molecular mechanisms underlying beneficial effects of CR, identification of pathways that can be targeted by CR-mimetics for future therapies. This project is expected to produce fundamental knowledge on the effects of ageing of neurons, astrocytes and microglia both in vitro and in vivo and on the mechanisms underlying caloric restriction -based improvement of their function. Based on the data obtained one shall be able to identify critical cellular/molecular pathways that can be targeted by CR-mimetics for future therapies.

Staff

Managers

Institute of Physiology
Non-clinical institutes, Faculty of Medicine

Local organizational units

Physiology II
Institute of Physiology
Non-clinical institutes, Faculty of Medicine

Funders

Hannover, Niedersachsen, Germany
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