Project SFB TRR 156/1 TP A01 – How skin inflammation is shaped by interaction of Staphylococcus aureus with skin cells and…

Basic data

Acronym:
SFB TRR 156/1 TP A01
Title:
How skin inflammation is shaped by interaction of Staphylococcus aureus with skin cells and skin microbiota
Duration:
01/07/2015 to 30/06/2019
Abstract / short description:
The skin of atopic dermatitis (AD) patients but not of healthy individuals is usually colonized by Staphylococcus aureus, which is thought to contribute to skin inflammation. The capacities of S. aureus to prevail in AD skin microbiota and modulate skin inflammation have hardly been investigated. We have explored pro- and anti-inflammatory S. aureus molecules, studied mechanisms of microbiota interaction, and established in vitro and in vivo skin colonization models. We will analyse how S. aureus adjusts a favourable level of skin inflammation and which role bacteriocins or metabolic capacities play in the competition with other skin bacteria. Our project should help to find new ways for treating bacteria-associated skin disorders.

Involved staff

Managers

Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes

Contact persons

Department of Dermatology
Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Interfaculty Institute of Microbiology and Infection Medicine (IMIT)
Interfaculty Institutes
University of Tübingen

Funders

Bonn, Nordrhein-Westfalen, Germany
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