Project HDAC inhibition protects degenerating cone photoreceptors in vivo

Basic data

Title:
HDAC inhibition protects degenerating cone photoreceptors in vivo
Duration:
01/09/2015 to 29/02/2016
Abstract / short description:
Hereditary cone degenerations, such as in Stargardt and Best disease, achromatopsia and cone dystrophies are caused by mutations in single genes, and lead to severe visual impairment, reduced visual acuity, and loss of color vision. We have previously shown that in an animal model for cone photoreceptor degeneration (cpfl1 mouse) follows a non-apoptotic cell death mechanism characterized by increased HDAC activity at the peak of degeneration (Arango-Gonzalez et al., PLoS One, 9:e112142, 2014). We will study the protective effects of HDAC inhibition to identify and define therapeutic window of opportunity. The use of cpfl1 animals should facilitate clinical translation to human diseases affecting cone survival and cone migration, such as cone dystrophies, age-related macular degeneration and diabetic retinopathy.
Keywords:
neuroprotection
Neuroprotektion
TSA
Valproic acid

Involved staff

Managers

Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine

Contact persons

Research Center for Ophthalmology
Center for Ophthalmology, Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Research Center for Ophthalmology
Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine

Funders

Tübingen, Baden-Württemberg, Germany
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