Project PersonalMed – Personalized medicine: PARP inhibition as a means to save photoreceptors in Pde6a mutant mouse…

Basic data

Acronym:
PersonalMed
Title:
Personalized medicine: PARP inhibition as a means to save photoreceptors in Pde6a mutant mouse retina, genotype matched to human Retinitis Pigmentosa patients
Duration:
01/07/2015 to 30/06/2016
Abstract / short description:
Retinitis Pigmentosa (RP) relates to a heterogeneous group of blinding diseases, which collectively affect about 1 in 4000 individuals worldwide. The enzyme poly(ADP-ribose) polymerase (PARP) has recently been shown to be involved in the degeneration of photoreceptors in a variety of animal models for RP (Arango-Gonzalez et al., PLoS One, 9:e112142, 2014). To test whether PARP is also responsible for photoreceptor loss caused by mutations in the PDE6A gene, we will use mouse models homozygous for the V685M, R562W, and D670G mutations in Pde6a. Since homozygosity for mutant alleles is very rare in human RD patients, we will also evaluate compound heterozygous Pde6aV685M/R562W animals, which are genotype matched to human RP patients.
Keywords:
neuroprotection
Neuroprotektion
cGMP signalling
HDAC

Involved staff

Managers

Research Center for Ophthalmology
Center for Ophthalmology, Hospitals and clinical institutes, Faculty of Medicine

Local organizational units

Research Center for Ophthalmology
Center for Ophthalmology
Hospitals and clinical institutes, Faculty of Medicine

Funders

Tübingen, Baden-Württemberg, Germany
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